IUBMB Enzyme Nomenclature

EC 1.21.3.2

Accepted name: columbamine oxidase

Reaction: 2 columbamine + O2 = 2 berberine + 2 H2O

For diagram click here.

Other name(s): berberine synthase

Systematic name: columbamine:oxygen oxidoreductase (cyclizing)

Comments: An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 95329-18-3

References:

1. Rueffer, M. and Zenk, M.H. Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. Tetrahedron Lett. 26 (1985) 201-202.

[EC 1.21.3.2 created 1989 as EC 1.1.3.26, transferred 2002 to EC 1.21.3.2]


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