IUBMB Enzyme Nomenclature


Accepted name: columbamine oxidase

Reaction: 2 columbamine + O2 = 2 berberine + 2 H2O

For diagram click here.

Other name(s): berberine synthase

Systematic name: columbamine:oxygen oxidoreductase (cyclizing)

Comments: An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 95329-18-3


1. Rueffer, M. and Zenk, M.H. Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. Tetrahedron Lett. 26 (1985) 201-202.

[EC created 1989 as EC, transferred 2002 to EC]

Return to EC 1.21.3 home page
Return to EC 1.21 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page