IUBMB Enzyme Nomenclature


Accepted name: tetrachlorohydroquinone reductive dehalogenase

Reaction: (1) 2,6-dichlorohydroquinone + Cl- + glutathione disulfide = 2,3,6-trichlorohydroquinone + 2 glutathione
(2) 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione

Other name(s): pcpC (gene name)

Systematic name: glutathione disulfide:2,6-dichlorohydroquinone (chlorinating)

Comments: The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Xun, L., Topp, E. and Orser, C.S. Purification and characterization of a tetrachloro-p-hydroquinone reductive dehalogenase from a Flavobacterium sp. J. Bacteriol. 174 (1992) 8003-8007. [PMID: 1459949]

2. McCarthy, D.L., Navarrete, S., Willett, W.S., Babbitt, P.C. and Copley, S.D. Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily. Biochemistry 35 (1996) 14634-14642. [PMID: 8931562]

[EC created 2018]

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