Reaction: 3-(2-hydroxyphenyl)propanoate + NAD+ = 2-coumarate + NADH + H+
Other name(s): melilotate dehydrogenase
Systematic name: 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase
Comments: The enzyme, isolated from an Arthrobacter species, is highly specific for 2-coumarate. cf. EC 1.3.1.130, hydroxycinnamate reductase.
Links to other databases: BRENDA, EXPASY, GENE, KEGG, MetaCyc, CAS registry number: 37251-10-8
References:
1. Levy, C. C. Metabolism of coumarin by a micro-organism: o-coumaric acid as an intermediate between coumarin and melilotic acid. Nature 204 (1964) 1059-1061. [PMID: 14243380]
2. Levy, C.C. and Weinstein, G.D. The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid. Biochemistry 3 (1964) 1944-1947. [PMID: 14269315]