IUBMB Enzyme Nomenclature


Accepted name: prephenate dehydrogenase

Reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

For diagram click here.

Other name(s): hydroxyphenylpyruvate synthase; chorismate mutase—prephenate dehydrogenase

Systematic name: prephenate:NAD+ oxidoreductase (decarboxylating)

Comments: This enzyme in the enteric bacteria also possesses chorismate mutase activity (EC chorismate mutase) and converts chorismate into prephenate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9044-92-2


1. Koch, G.L.E., Shaw, D.C. and Gibson, F. Tyrosine biosynthesis in Aerobacter aerogenes. Purification and properties of chorismate mutase-prephenate dehydrogenase. Biochim. Biophys. Acta 212 (1970) 375-386. [PMID: 5456988]

[EC created 1972]

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