Reaction: (1) a (3E)-3-enoyl-CoA + NADP+ = a (2E,4E)-2,4-dienoyl-CoA + NADPH + H+
(2) a (3E)-3-enoyl-CoA + NADP+ = a (2E,4Z)-2,4-dienoyl-CoA + NADPH + H+
Other name(s): SPS19 (gene name); DECR1 (gene name); DECR2 (gene name); Δ2,Δ4-dienoyl-CoA reductase (ambiguous)
Systematic name: (3E)-3-enoyl-CoA:NADP+ 4-oxidoreductase
Comments: This enzyme, characterized from eukaryotic organisms, catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (3E)-3-enoyl-CoA. The best substrates for the enzyme from bovine liver have a chain-length of 8 or 10 carbons. Mammals possess both mitochondrial and peroxisomal variants of this enzyme. cf. EC 1.3.1.34, 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:
References:
1. Kunau, W.-H. and Dommes, P. Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoly-CoA by extracts of beef-liver mitochondria. Eur. J. Biochem. 91 (1978) 533-544. [PMID: 729581]
2. Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. Eur. J. Biochem. 125 (1982) 335-341. [PMID: 6749495]
3. Gurvitz, A., Rottensteiner, H., Kilpelainen, S.H., Hartig, A., Hiltunen, J.K., Binder, M., Dawes, I.W. and Hamilton, B. The Saccharomyces cerevisiae peroxisomal 2,4-dienoyl-CoA reductase is encoded by the oleate-inducible gene SPS19. J. Biol. Chem. 272 (1997) 22140-22147. [PMID: 9268358]
4. Geisbrecht, B.V., Liang, X., Morrell, J.C., Schulz, H. and Gould, S.J. The mouse gene PDCR encodes a peroxisomal δ2, δ4-dienoyl-CoA reductase. J. Biol. Chem. 274 (1999) 25814-25820. [PMID: 10464321]
5. De Nys, K., Meyhi, E., Mannaerts, G.P., Fransen, M. and Van Veldhoven, P.P. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. Biochim. Biophys. Acta 1533 (2001) 66-72. [PMID: 11514237]
6. Alphey, M.S., Yu, W., Byres, E., Li, D. and Hunter, W.N. Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site. J. Biol. Chem. 280 (2005) 3068-3077. [PMID: 15531764]