Reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
For diagram of reaction click here.
Other name(s): dihydrothymine dehydrogenase; dihydrouracil dehydrogenase (NADP); 4,5-dihydrothymine: oxidoreductase; DPD; DHPDH; dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate); dihydrouracil dehydrogenase (NADP); DHU dehydrogenase; hydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase (NADP)
Systematic name: 5,6-dihydrouracil:NADP+ 5-oxidoreductase
Comments: Also acts on dihydrothymine.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-01-0
References:
1. Fritzson, P. Properties and assay of dihydrouracil dehydrogenase of rat liver. J. Biol. Chem. 235 (1960) 719-725.
2. Shiotani, T. and Weber, G. Purification and properties of dihydrothymine dehydrogenase from rat liver. J. Biol. Chem. 256 (1981) 219-224. [PMID: 7451435]