IUBMB Enzyme Nomenclature


Accepted name: dihydropyrimidine dehydrogenase (NADP+)

Reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+

For diagram of reaction click here.

Other name(s): dihydrothymine dehydrogenase; dihydrouracil dehydrogenase (NADP); 4,5-dihydrothymine: oxidoreductase; DPD; DHPDH; dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate); dihydrouracil dehydrogenase (NADP); DHU dehydrogenase; hydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase (NADP)

Systematic name: 5,6-dihydrouracil:NADP+ 5-oxidoreductase

Comments: Also acts on dihydrothymine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-01-0


1. Fritzson, P. Properties and assay of dihydrouracil dehydrogenase of rat liver. J. Biol. Chem. 235 (1960) 719-725.

2. Shiotani, T. and Weber, G. Purification and properties of dihydrothymine dehydrogenase from rat liver. J. Biol. Chem. 256 (1981) 219-224. [PMID: 7451435]

[EC created 1961, modified 1986]

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