IUBMB Enzyme Nomenclature


Accepted name: trans-2-enoyl-CoA reductase (NAD+)

Reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH + H+

Other name(s): trans-2-enoyl-CoA reductase (NAD)

Systematic name: acyl-CoA:NAD+ trans-2-oxidoreductase

Comments: The enzyme from Euglena gracilis acts on crotonoyl-CoA and, more slowly, on trans-hex-2-enoyl-CoA and trans-oct-2-enoyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 77649-64-0


1. Inui, H., Miyatake, K., Nakano, Y. and Kitaoka, S. Purification and some properties of short chain-length specific trans-2-enoyl-CoA reductase in mitochondria of Euglena gracilis. J. Biochem. (Tokyo) 100 (1986) 995-1000. [PMID: 3102464]

[EC created 1989]

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