IUBMB Enzyme Nomenclature


Accepted name: Δ24-sterol reductase

Reaction: 5α-cholest-7-en-3β-ol + NADP+ = 5α-cholesta-7,24-dien-3β-ol + NADPH + H+

For diagram click here.

desmosterol = cholesta-5,24-dien-3β-ol
lanosterol = 4,4,14-trimethyl-5α-cholesta-8,24-dien-3β-ol
zymostrol = 5α-cholesta-8,24-dien-3β-ol

Other names: lanosterol Δ24-reductase

Systematic name: sterol:NADP+ Δ24-oxidoreductase

Comments: Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9033-57-2


1. Bae, S.H. and Paik, Y.K. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol Δ24-reductase. Biochem. J. 326 (1997) 609-616. [PMID: 9291139]

[EC created 2001]

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