Reaction: 17-O-acetylnorajmaline + NADP+ = (2R)-1,2-dihydrovomilenine + NADPH + H+
For diagram of reaction, click here
Other name(s): 1,2-dihydrovomilenine reductase; DHVR; RR4 (gene name); 17-O-acetylnorajmaline:NADP+ oxidoreductase
Systematic name: 17-O-acetylnorajmaline:NADP+ 19,20-oxidoreductase
Comments: The enzyme, characterized from the plant Rauvolfia serpentina, participates in the ajmaline biosynthesis pathway. It has a much lower activity on vomilenine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Gao, S., von Schumann, G. and Stöckigt, J. A newly-detected reductase from Rauvolfia closes a gap in the biosynthesis of the antiarrhythmic alkaloid ajmaline. Planta Med. 68 (2002) 906-911. [PMID: 12391554]
2. Guo, J., Gao, D., Lian, J. and Qu, Y. De novo biosynthesis of antiarrhythmic alkaloid ajmaline. Nat. Commun. 15 (2024) 457. [PMID: 38212296]