IUBMB Enzyme Nomenclature


Accepted name: arogenate dehydrogenase [NAD(P)+]

Reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2

For diagram click here.

Glossary: L-arogenate = 1-[(2S)-2-amino-2-carboxyethyl]-4-hydroxycyclohexa-2,5-diene-1-carboxylate

Other name(s): arogenic dehydrogenase (ambiguous); cyclohexadienyl dehydrogenase; pretyrosine dehydrogenase (ambiguous)

Systematic name: L-arogenate:NAD(P)+ oxidoreductase (decarboxylating)

Comments: Arogenate dehydrogenases may utilize NAD+ (EC, NADP+ (EC, or both (EC Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 64295-75-6


1. Byng, G.S., Whitaker, R.J., Gherna, R.L. and Jensen, R.A. Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. J. Bacteriol. 144 (1980) 247–257. [PMID: 7419490]

[EC created 2005]

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