Reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+
Other name(s): 2-enoyl-CoA reductase; dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate); enoyl coenzyme A reductase; crotonyl coenzyme A reductase; crotonyl-CoA reductase; acyl-CoA dehydrogenase (NADP)
Systematic name: acyl-CoA:NADP+ 2-oxidoreductase
Comments: The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC 126.96.36.199 cis-2-enoyl-CoA reductase (NADPH) and EC 188.8.131.52 trans-2-enoyl-CoA reductase (NADPH)].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37251-07-3
1. Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H. Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli. Eur. J. Biochem. 125 (1982) 335-341. [PMID: 6749495]
2. Seubert, W., Lamberts, I., Kramer, R. and Ohly, B. On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA. Biochim. Biophys. Acta 164 (1968) 498-517. [PMID: 4387390]