IUBMB Enzyme Nomenclature


Accepted name: tRNA-dihydrouridine16/17 synthase [NAD(P)+]

Reaction: (1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ = uracil16 in tRNA + NAD(P)H + H+
(2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ = uracil17 in tRNA + NAD(P)H + H+

Other name(s): Dus1p; tRNA-dihydrouridine synthase 1

Systematic name: tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase

Comments: A flavoprotein. The enzyme specifically modifies uracil16 and uracil17 in tRNA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J. Biol. Chem. 279 (2004) 17850-17860. [PMID: 14970222]

2. Xing, F., Martzen, M.R. and Phizicky, E.M. A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA 8 (2002) 370-381. [PMID: 12003496]

[EC created 2011]

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