Reaction: 5,6-dihydrouracil47 in tRNA + NAD(P)+ = uracil47 in tRNA + NAD(P)H + H+
Other name(s): Dus3p; tRNA-dihydrouridine synthase 3
Systematic name: tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase
Comments: A flavoenzyme. The enzyme specifically modifies uracil47 in tRNA.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J. Biol. Chem. 279 (2004) 17850-17860. [PMID: 14970222]