IUBMB Enzyme Nomenclature


Accepted name: acrylyl-CoA reductase (NADH)

Reaction: propanoyl-CoA + NAD+ = acrylyl-CoA + NADH + H+

For diagram of reaction click here.

Glossary: propanoyl-CoA = propionyl-CoA

Systematic name: propanoyl-CoA:NAD+ oxidoreductase

Comments: Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC, acrylyl-CoA reductase (NADPH).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hetzel, M., Brock, M., Selmer, T., Pierik, A.J., Golding, B.T. and Buckel, W. Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein. Eur. J. Biochem. 270 (2003) 902-910. [PMID: 12603323]

2. Kandasamy, V., Vaidyanathan, H., Djurdjevic, I., Jayamani, E., Ramachandran, K.B., Buckel, W., Jayaraman, G. and Ramalingam, S. Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation. Appl. Microbiol. Biotechnol. (2012) . [PMID: 22810300]

[EC created 2012]

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