IUBMB Enzyme Nomenclature


Accepted name: Botryococcus squalene synthase

Reaction: squalene + diphosphate + NADP+ = presqualene diphosphate + NADPH + H+

For diagram of reaction click here.

Other name(s): SSL-2 (gene name)

Systematic name: squalene:NADP+ oxidoreductase

Comments: Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC, squalene synthase, where squalene is formed directly from farnesyl diphosphate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Niehaus, T.D., Okada, S., Devarenne, T.P., Watt, D.S., Sviripa, V. and Chappell, J. Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii. Proc. Natl. Acad. Sci. USA 108 (2011) 12260-12265. [PMID: 21746901]

[EC created 2012]

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