IUBMB Enzyme Nomenclature


Accepted name: protoporphyrinogen IX dehydrogenase (quinone)

Reaction: protoporphyrinogen IX + 3 quinone = protoporphyrin IX + 3 quinol

Other name(s): HemG; protoporphyrinogen IX dehydrogenase (menaquinone)

Systematic name: protoporphyrinogen IX:quinone oxidoreductase

Comments: Contains FMN. The enzyme participates in heme b biosynthesis. In the bacterium Escherichia coli it interacts with either ubiquinone or menaquinone, depending on whether the organism grows aerobically or anaerobically.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Boynton, T.O., Daugherty, L.E., Dailey, T.A. and Dailey, H.A. Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity. Biochemistry 48 (2009) 6705-6711. [PMID: 19583219]

2. Möbius, K., Arias-Cartin, R., Breckau, D., Hännig, A.L., Riedmann, K., Biedendieck, R., Schroder, S., Becher, D., Magalon, A., Moser, J., Jahn, M. and Jahn, D. Heme biosynthesis is coupled to electron transport chains for energy generation. Proc. Natl. Acad. Sci. USA 107 (2010) 10436-10441. [PMID: 20484676]

[EC created 2010, modified 2020]

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