IUBMB Enzyme Nomenclature


Accepted name: dehydro coenzyme F420 reductase

Reaction: oxidized coenzyme F420-0 + FMN = dehydro coenzyme F420-0 + FMNH2

Glossary: dehydro coenzyme F420-0 = 2-{[5-deoxy-5-(8-hydroxy-2,4-dioxopyrimidino[4,5-b]quinolin-10(2H)-yl)-L-ribityloxy]hydroxyphosphoryloxy}prop-2-enoate

Other name(s): fbiB (gene name)

Systematic name: oxidized coenzyme F420-0:FMN oxidoreductase

Comments: This enzyme is involved in the biosynthesis of coenzyme F420, a redox-active cofactor found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC, coenzyme F420-0:L-glutamate ligase, and EC, coenzyme F420-1:γ-L-glutamate ligase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Bashiri, G., Antoney, J., Jirgis, E.NM., Shah, M.V., Ney, B., Copp, J., Stuteley, S.M., Sreebhavan, S., Palmer, B., Middleditch, M., Tokuriki, N., Greening, C., Scott, C., Baker, E.N. and Jackson, C.J. A revised biosynthetic pathway for the cofactor F420 in prokaryotes. Nat. Commun. 10 (2019) 1558. [PMID: 30952857]

[EC created 2021]

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