IUBMB Enzyme Nomenclature


Accepted name: isoquinoline 1-oxidoreductase

Reaction: isoquinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor

Systematic name: isoquinoline:acceptor 1-oxidoreductase (hydroxylating)

Comments: the enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 155948-73-5


1. Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase. J. Biol. Chem. 269 (1994) 11254-11260. [PMID: 8157655]

2. Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases. J. Biol. Chem. 270 (1995) 14420-14429. [PMID: 7782304]

[EC created 1999]

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