IUBMB Enzyme Nomenclature


Accepted name: quinoline-4-carboxylate 2-oxidoreductase

Reaction: quinoline-4-carboxylate + acceptor + H2O = 2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced acceptor

For diagram, click here

Other name(s): quinaldic acid 4-oxidoreductase; quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)

Systematic name: quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating)

Comments: A molybdenum—iron—sulfur flavoprotein with molybdopterin cytosine dinucleotide as the molybdenum cofactor. Quinoline, 4-methylquinoline and 4-chloroquinoline can also serve as substrates for the enzyme from Agrobacterium sp. 1B. Iodonitrotetrazolium chloride, thionine, menadione and 2,6-dichlorophenolindophenol can act as electron acceptors.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 175780-18-4


1. Bauer, G. and Lingens, F. Microbial metabolism of quinoline and related compounds. XV. Quinoline-4-carboxylic acid oxidoreductase from Agrobacterium spec.1B: a molybdenum-containing enzyme. Biol. Chem. Hoppe-Seyler 373 (1992) 699-705. [PMID: 1418685]

[EC created 1999, modified 2006]

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