IUBMB Enzyme Nomenclature


Accepted name: 3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase

Reaction: 3-(methylsulfanyl)propanoyl-CoA + acceptor = 3-(methylsulfanyl)acryloyl-CoA + reduced acceptor

Other name(s): dmdC (gene name)

Systematic name: 3-(methylsulfanyl)propanoyl-CoA:acceptor 2-oxidoreductase

Comments: The enzyme, found in marine bacteria, participates in a 3-(methylsulfanyl)propanoate degradation pathway. Based on similar enzymes, the in vivo electron acceptor is likely electron-transfer flavoprotein (ETF).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Reisch, C.R., Stoudemayer, M.J., Varaljay, V.A., Amster, I.J., Moran, M.A. and Whitman, W.B. Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria. Nature 473 (2011) 208-211. [PMID: 21562561]

2. Bullock, H.A., Luo, H. and Whitman, W.B. Evolution of dimethylsulfoniopropionate metabolism in marine phytoplankton and bacteria. Front. Microbiol. 8 (2017) 637. [PMID: 28469605]

3. Shao, X., Cao, H.Y., Zhao, F., Peng, M., Wang, P., Li, C.Y., Shi, W.L., Wei, T.D., Yuan, Z., Zhang, X.H., Chen, X.L., Todd, J.D. and Zhang, Y.Z. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol. Microbiol. 111 (2019) 1057-1073. [PMID: 30677184]

[EC created 2022]

Return to EC 1.3.99 home page
Return to EC 1.3 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page