Reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+
Systematic name: L-valine:NAD+ oxidoreductase (deaminating)
Comments: The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC 1.4.1.8, valine dehydrogenase (NADP+)].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Vancurová, I., Vancura, A., Volc, J., Neuzil, J., Flieger, M., Basarová, G. and Behal, V. Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens. J. Bacteriol. 170 (1988) 5192-5196. [PMID: 3182727]
2. Navarrete, R.M., Vara, J.A. and Hutchinson, C.R. Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). J. Gen. Microbiol. 136 (1990) 273-281. [PMID: 2324704]