IUBMB Enzyme Nomenclature


Accepted name: valine dehydrogenase (NAD+)

Reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH + H+

Systematic name: L-valine:NAD+ oxidoreductase (deaminating)

Comments: The enzyme from Streptomyces spp. has no activity with NADP+ [cf. EC, valine dehydrogenase (NADP+)].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Vancurová, I., Vancura, A., Volc, J., Neuzil, J., Flieger, M., Basarová, G. and Behal, V. Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens. J. Bacteriol. 170 (1988) 5192-5196. [PMID: 3182727]

2. Navarrete, R.M., Vara, J.A. and Hutchinson, C.R. Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2). J. Gen. Microbiol. 136 (1990) 273-281. [PMID: 2324704]

[EC created 2012]

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