IUBMB Enzyme Nomenclature


Accepted name: protein-lysine 6-oxidase

Reaction: peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2

Other name(s): lysyl oxidase

Systematic name: protein-L-lysine:oxygen 6-oxidoreductase (deaminating)

Comments: Also acts on protein 5-hydroxylysine. This enzyme catalyses the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices [4]. These reactions play an important role for the development, elasticity and extensibility of connective tissue. The enzyme is also active on free amines, such as cadaverine or benzylamine [4,5]. Some isoforms can also use [protein]-N(6)-acetyl-L-lysine as substrate deacetamidating the substrate [6].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 99676-44-5


1. Harris, E.D., Gonnerman, W.A., Savage, J.E. and O'Dell, B.L. Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta. Biochim. Biophys. Acta 341 (1974) 332-344. [PMID: 4838158]

2. Rayton, J.K. and Harris, E.D. Induction of lysyl oxidase with copper. Properties of an in vitro system. J. Biol. Chem. 254 (1979) 621-626. [PMID: 33171]

3. Stassen, F.L.H. Properties of highly purified lysyl oxidase from embryonic chick cartilage. Biochim. Biophys. Acta 438 (1976) 49-60. [PMID: 7318]

4. Palamakumbura, A.H. and Trackman, P.C. A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. Anal. Biochem. 300 (2002) 245-251. [PMID: 11779117]

5. Kagan, H.M., Williams, M.A., Williamson, P.R. and Anderson, J.M. Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates. J. Biol. Chem. 259 (1984) 11203-11207. [PMID: 6147351]

6. Rodriguez, H.M., Vaysberg, M., Mikels, A., McCauley, S., Velayo, A.C., Garcia, C. and Smith, V. Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor. J. Biol. Chem. 285 (2010) 20964-20974. [PMID: 20439985]

7. Kim, Y.M., Kim, E.C. and Kim, Y. The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin. Mol. Biol. Rep. 38 (2011) 145-149. [PMID: 20306300]

8. Xu, L., Go, E.P., Finney, J., Moon, H., Lantz, M., Rebecchi, K., Desaire, H. and Mure, M. Post-translational modifications of recombinant human lysyl oxidase-like 2 (rhLOXL2) secreted from Drosophila S2 cells. J. Biol. Chem. 288 (2013) 5357-5363. [PMID: 23319596]

9. Ma, L., Huang, C., Wang, X.J., Xin, D.E., Wang, L.S., Zou, Q.C., Zhang, Y.S., Tan, M.D., Wang, Y.M., Zhao, T.C., Chatterjee, D., Altura, R.A., Wang, C., Xu, Y.S., Yang, J.H., Fan, Y.S., Han, B.H., Si, J., Zhang, X., Cheng, J., Chang, Z. and Chin, Y.E. Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation. Mol. Cell 65 (2017) 296-309. [PMID: 28065600]

[EC created 1980, modified 1983]

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