IUBMB Enzyme Nomenclature


Accepted name: glycine oxidase

Reaction: glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (overall reaction)
(1a) glycine + O2 = 2-iminoacetate + H2O2
(1b) 2-iminoglycine + H2O = glyoxylate + NH3

For diagram of reaction click here

Systematic name: glycine:oxygen oxidoreductase (deaminating)

Comments: A flavoenzyme containing non-covalently bound FAD. The enzyme from Bacillus subtilis is active with glycine, sarcosine, N-ethylglycine, D-alanine, D-α-aminobutyrate, D-proline, D-pipecolate and N-methyl-D-alanine. It differs from EC, D-amino-acid oxidase, due to its activity on sarcosine and D-pipecolate. The intermediate 2-iminoacetate is used directly by EC, thiazole synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 39307-16-9


1. Job, V., Marcone, G.L., Pilone, M.S. and Pollegioni, L. Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein. J. Biol. Chem. 277 (2002) 6985-6993. [PMID: 11744710]

2. Nishiya, Y. and Imanaka, T. Purification and characterization of a novel glycine oxidase from Bacillus subtilis. FEBS Lett. 438 (1998) 263-266. [PMID: 9827558]

[EC created 2002, modified 2012]

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