IUBMB Enzyme Nomenclature


Accepted name: ephedrine dehydrogenase

Reaction: (–)-ephedrine + NAD+ = (R)-2-methylimino-1-phenylpropan-1-ol + NADH + H+

Systematic name: (–)-ephedrine:NAD+ 2-oxidoreductase

Comments: The product immediately hydrolyses to methylamine and 1-hydroxy-1-phenylpropan-2-one. Acts on a number of related compounds including (–)-sympatol, (+)-pseudoephedrine and (+)-norephedrine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 73508-06-2


1. Klamann, E. and Lingens, F. Degradation of (–)-ephedrine by Pseudomonas putida. Detection of (–)-ephedrine: NAD+-oxidoreductase from Arthrobacter globiformis. Z. Naturforsch. C: Biosci. 35 (1980) 80-87. [PMID: 7405363]

[EC created 1984]

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