IUBMB Enzyme Nomenclature


Accepted name: pyrroline-5-carboxylate reductase

Reaction: L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H + H+

For diagram click here.

Other name(s): proline oxidase; L-proline oxidase; 1-pyrroline-5-carboxylate reductase; NADPH-L1-pyrroline carboxylic acid reductase; L-proline-NAD(P)+ 5-oxidoreductase

Systematic name: L-proline:NAD(P)+ 5-oxidoreductase

Comments: Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9029-17-8


1. Adams, E. and Goldstone, A. Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from δ1-pyrroline-3-hydroxy-5-carboxylate. J. Biol. Chem. 235 (1960) 3499-3503.

2. Meister, A., Radhakrishnan, A.N. and Buckley, S.D. Enzymatic synthesis of L-pipecolic acid and L-proline. J. Biol. Chem. 229 (1957) 789-800.

3. Smith, M.E. and Greenberg, D.M. Characterization of an enzyme reducing pyrroline-5-carboxylate to proline. Nature (Lond.) 177 (1956) 1130.

4. Yura, T. and Vogel, H.J. Pyrroline-5-carboxylate reductase of Neurospora crassa: partial purification and some properties. J. Biol. Chem. 234 (1959) 335-338.

[EC created 1961]

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