IUBMB Enzyme Nomenclature


Accepted name: 1,2-dehydroreticulinium reductase (NADPH)

Reaction: (R)-reticuline + NADP+ = 1,2-dehydroreticulinium + NADPH + H+

For diagram click here.

Other name(s): 1,2-dehydroreticulinium ion reductase

Systematic name: (R)-reticuline:NADP+ oxidoreductase

Comments: Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 130590-58-8


1. De-Eknamkul, W. and Zenk, M.H. Purification and properties of 1,2-dehydroreticulinium reductase from Papaver somniferum seedlings. Phytochemistry 31 (1992) 813-821.

[EC created 1999, modified 2004]

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