IUBMB Enzyme Nomenclature


Accepted name: festuclavine dehydrogenase

Reaction: festuclavine + NAD+ = 6,8-dimethyl-6,7-didehydroergoline + NADH + H+

For diagram of reaction click here.

Glossary: festuclavine = 6,8β-dimethylergoline

Other name(s): FgaFS; festuclavine synthase

Systematic name: festuclavine:NAD+ oxidoreductase

Comments: The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Wallwey, C., Matuschek, M., Xie, X.L. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3. Org. Biomol. Chem. 8 (2010) 3500-3508. [PMID: 20526482]

[EC created 2012]

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