IUBMB Enzyme Nomenclature


Accepted name: agroclavine dehydrogenase

Reaction: agroclavine + NADP+ = 6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+

For diagram of reaction click here.

Glossary: agroclavine = 6,8-dimethyl-8,9-didehydroergoline

Other name(s): easG (gene name)

Systematic name: agroclavine:NADP+ oxidoreductase

Comments: The enzyme participates in the biosynthesis of ergotamine, an ergot alkaloid produced by some fungi of the Clavicipitaceae family. The reaction is catalysed in the opposite direction to that shown. The substrate for the enzyme is an iminium intermediate that is formed spontaneously from chanoclavine-I aldehyde in the presence of glutathione.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Matuschek, M., Wallwey, C., Xie, X. and Li, S.M. New insights into ergot alkaloid biosynthesis in Claviceps purpurea: an agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine. Org. Biomol. Chem. 9 (2011) 4328-4335. [PMID: 21494745]

[EC created 2013]

Return to EC 1.5.1 home page
Return to EC 1.5 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page