IUBMB Enzyme Nomenclature


Accepted name: 2-methyl-1-pyrroline reductase

Reaction: (R)-2-methylpyrrolidine + NADP+ = 2-methyl-1-pyrroline + NADPH + H+

Other name(s): (R)-imine reductase (ambiguous)

Systematic name: (R)-2-methylpyrrolidine:NADP+ 2-oxidoreductase

Comments: The enzyme from the bacterium Streptomyces sp. GF3587 is highly specific for its substrate and forms only the (R) isomer.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Mitsukura, K., Suzuki, M., Shinoda, S., Kuramoto, T., Yoshida, T. and Nagasawa, T. Purification and characterization of a novel (R)-imine reductase from Streptomyces sp. GF3587. Biosci. Biotechnol. Biochem. 75 (2011) 1778-1782. [PMID: 21897027]

[EC created 2014]

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