Reaction: N1-[(S)-3-amino-3-carboxypropyl]agamatine + NADP+ + H2O = agmatine + L-aspartate 4-semialdehyde + NADPH + H+
Glossary: N1-[(S)-3-amino-3-carboxypropyl]agamatine = carboxyaminopropylagmatine
L-aspartate 4-semialdehyde = L-aspartate β-semialdehyde
Other name(s): slr0049 (locus name)
Systematic name: N1-[(S)-2-aminobutanoate]agmatine:NADP+ oxidoreductase (agmatine-forming)
Comments: The enzyme, characterized from the cyanobacterium Synechocystis sp. PCC 6803, catalyses the reductive condensation of agmatine and L-aspartate 4-semialdehyde. It participates in a biosynthetic pathway for spermidine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Xi, H., Nie, X., Gao, F., Liang, X., Li, H., Zhou, H., Cai, Y. and Yang, C. A bacterial spermidine biosynthetic pathway via carboxyaminopropylagmatine. Sci Adv 9 (2023) eadj9075. [PMID: 37878710]