IUBMB Enzyme Nomenclature


Accepted name: N8-acetylspermidine oxidase (propane-1,3-diamine-forming)

Reaction: N8-acetylspermidine + O2 + H2O = propane-1,3-diamine + 4-acetamidobutanal + H2O2

Systematic name: N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming)

Comments: Also active with N1-acetylspermine, weak activity with N1,N12-diacetylspermine. No activity with diaminopropane, putrescine, cadaverine, diaminohexane, norspermidine, spermine and spermidine. Absence of monoamine oxidase (EC activity. Differs in specificity from EC (N1-acetylpolyamine oxidase), EC [polyamine oxidase (propane-1,3-diamine-forming)], EC (spermine oxidase) and EC (non-specific polyamine oxidase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Shukla, O.P., Muller, S. and Walter, R.D. Polyamine oxidase from Acanthamoeba culbertsoni specific for N8-acetylspermidine. Mol. Biochem. Parasitol. 51 (1992) 91-98. [PMID: 1565141]

[EC created 2009]

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