IUBMB Enzyme Nomenclature


Accepted name: L-saccharopine oxidase

Reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + H2O + O2 = (S)-2-amino-6-oxohexanoate + L-glutamate + H2O2

Glossary: L-saccharopine = N6-(L-1,3-dicarboxypropyl)-L-lysine
(S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine

Other name(s): FAP2

Systematic name: L-saccharopine:oxygen oxidoreductase (L-glutamate forming)

Comments: The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yoshida, N., Akazawa, S., Katsuragi, T. and Tani, Y. Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe. J. Biosci. Bioeng. 97 (2004) 278-280. [PMID: 16233628]

2. Wickwire, B.M., Wagner, C. and Broquist, H.P. Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis. J. Biol. Chem. 265 (1990) 14748-14753. [PMID: 2394693]

[EC created 2011]

Return to EC 1.5.3 home page
Return to EC 1.5 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page