IUBMB Enzyme Nomenclature


Accepted name: 4-methylaminobutanoate oxidase (methylamine-forming)

Reaction: 4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2

For diagram of reaction click here.

Other name(s): mao (gene name, ambiguous)

Systematic name: 4-methylaminobutanoate methylamidohydrolase

Comments: The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC activity with 4-aminobutanoate [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number:


1. Chiribau, C.B., Sandu, C., Fraaije, M., Schiltz, E. and Brandsch, R. A novel γ-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1. Eur. J. Biochem. 271 (2004) 4677-4684. [PMID: 15606755]

2. Chiribau, C.B., Mihasan, M., Ganas, P., Igloi, G.L., Artenie, V. and Brandsch, R. Final steps in the catabolism of nicotine. FEBS J. 273 (2006) 1528-1536. [PMID: 16689938]

[EC created 2012]

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