Reaction: 2-(methylaminoethyl)phosphonate + O2 + H2O = phosphonoacetaldehyde + methylamine + H2O2
Other name(s): pbfD (gene name); N-methyl-(2-aminoethyl)phosphonate oxidase
Systematic name: 2-(methylaminoethyl)phosphonate oxidase:oxygen oxidoreductase (phosphonoacetaldehyde-forming)
Comments: Contaions FAD. The enzyme also acts, with lower efficiency, on 2-aminoethylphosphonate, generating phosphonoacetaldehyde and ammonia. The enzyme from Acinetobacter baumannii also transformed 2-(dimethylaminoethyl)phosphonate with appreciable efficiency, generating dimethylamine in place of methylamine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Zangelmi, E., Ruffolo, F., Dinhof, T., Gerdol, M., Malatesta, M., Chin, J.P., Rivetti, C., Secchi, A., Pallitsch, K. and Peracchi, A. Deciphering the role of recurrent FAD-dependent enzymes in bacterial phosphonate catabolism. iScience 26 (2023) 108108. [PMID: 37876809]