IUBMB Enzyme Nomenclature


Accepted name: sarcosine dehydrogenase

Reaction: sarcosine + 5,6,7,8-tetrahydrofolate + oxidised [electron-transfer flavoprotein] = glycine + 5,10-methylenetetrahydrofolate + reduced electron-transfer flavoprotein

Other name(s): sarcosine N-demethylase; monomethylglycine dehydrogenase; sarcosine:(acceptor) oxidoreductase (demethylating); sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)

Systematic name: sarcosine, 5,6,7,8-tetrahydrofolate:electron-transferflavoprotein oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)

Comments: A flavoprotein (FMN) found in eukaryotes. In the absence of tetrahydrofolate the enzyme produces formaldehyde. cf. EC, sarcosine oxidase (formaldehyde-forming), and EC, sarcosine oxidase (5,10-methylenetetrahydrofolate-forming).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37228-65-2, 93389-49-2


1. Hoskins, D.D. and MacKenzie, C.G. Solubilization and electron transfer flavoprotein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase. J. Biol. Chem. 236 (1961) 177-183. [PMID: 13716069]

2. Frisell, W.R. and MacKenzie, C.G. Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase. J. Biol. Chem. 237 (1962) 94-98. [PMID: 13895406]

3. Wittwer, A.J. and Wagner, C. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. J. Biol. Chem. 256 (1981) 4109-4115. [PMID: 6163778]

4. Steenkamp, D.J. and Husain, M. The effect of tetrahydrofolate on the reduction of electron transfer flavoprotein by sarcosine and dimethylglycine dehydrogenases. Biochem. J. 203 (1982) 707-715. [PMID: 6180732]

[EC created 1972 as EC, transferred 2012 to EC, modified 2022]

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