IUBMB Enzyme Nomenclature


Accepted name: NAD(P)+ transhydrogenase (ferredoxin)

Reaction: NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster

Other name(s): NADH-dependent reduced ferredoxin:NADP+ oxidoreductase; Nfn; nfnAB (gene names)

Systematic name: NADH:NADP+, ferredoxin oxidoreductase

Comments: The iron-sulfur flavoprotein complex, isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Wang, S., Huang, H., Moll, J. and Thauer, R.K. NADP+ reduction with reduced ferredoxin and NADP+ reduction with NADH are coupled via an electron-bifurcating enzyme complex in Clostridium kluyveri. J. Bacteriol. 192 (2010) 5115-5123. [PMID: 20675474]

2. Demmer, J.K., Huang, H., Wang, S., Demmer, U., Thauer, R.K. and Ermler, U. Insights into flavin-based electron bifurcation via the NADH-dependent reduced ferredoxin:NADP oxidoreductase Structure. J. Biol. Chem. 290 (2015) 21985-21995. [PMID: 26139605]

3. Lubner, C.E., Jennings, D.P., Mulder, D.W., Schut, G.J., Zadvornyy, O.A., Hoben, J.P., Tokmina-Lukaszewska, M., Berry, L., Nguyen, D.M., Lipscomb, G.L., Bothner, B., Jones, A.K., Miller, A.F., King, P.W., Adams, M.WW. and Peters, J.W. Mechanistic insights into energy conservation by flavin-based electron bifurcation. Nat. Chem. Biol. 13 (2017) 655-659. [PMID: 28394885]

[EC created 2015]

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