IUBMB Enzyme Nomenclature


Accepted name: demethylphylloquinone reductase

Reaction: demethylphylloquinone + NADPH + H+ = demethylphylloquinol + NADP+

Glossary: demethylphylloquinone = 2-phytyl-1,4-naphthoquinone

Other name(s): ndbB (gene name); NDC1 (gene name)

Systematic name: NADPH:demethylphylloquinone oxidoreductase

Comments: The enzyme, found in plants and cyanobacteria, is involved in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is a type II NADPH dehydrogenase and requires a flavine adenine dinucleotide cofactor.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Fatihi, A., Latimer, S., Schmollinger, S., Block, A., Dussault, P.H., Vermaas, W.F., Merchant, S.S. and Basset, G.J. A dedicated type II NADPH dehydrogenase performs the penultimate step in the biosynthesis of vitamin K1 in Synechocystis and Arabidopsis. Plant Cell 27 (2015) 1730-1741. [PMID: 26023160]

[EC created 2015]

Return to EC 1.6.5 home page
Return to EC 1.6 home page
Return to EC 1 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page