IUBMB Enzyme Nomenclature


Accepted name: NADPH dehydrogenase

Reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor

Other name(s): NADPH2 diaphorase; NADPH diaphorase; OYE; diaphorase; dihydronicotinamide adenine dinucleotide phosphate dehydrogenase; NADPH-dehydrogenase; NADPH-diaphorase; NADPH2-dehydrogenase; old yellow enzyme; reduced nicotinamide adenine dinucleotide phosphate dehydrogenase; TPNH dehydrogenase; TPNH-diaphorase; triphosphopyridine diaphorase; triphosphopyridine nucleotide diaphorase; NADPH2 dehydrogenase; NADPH:(acceptor) oxidoreductase

Systematic name: NADPH:acceptor oxidoreductase

Comments: A flavoprotein (FMN in yeast, FAD in plants).

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9001-68-7


1. Åkesson, Å., Ehrenberg, A. and Theorell, H. Old yellow enzyme. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Ed.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 477-494.

2. Avron, M. and Jagendorf, A.T. Some further investigations on chloroplast TPNH diaphorase. Arch. Biochem. Biophys. 72 (1957) 17-24.

3. Jagendorf, A.T. Chloroplast TPNH diaphorase. Methods Enzymol. 6 (1963) 430-434.

4. Theorell, H. Das gelbe Oxydationsferment. Biochem. Z. 278 (1935) 263-290.

5. Theorell, H. and Åkesson, Å. Molecular weight and FMN content of crystalline "old yellow enzyme". Arch. Biochem. Biophys. 65 (1956) 439-448.

[EC created 1961, modified 1976]

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