IUBMB Enzyme Nomenclature


Accepted name: N-hydroxy-2-acetamidofluorene reductase

Reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+

Other name(s): N-hydroxy-2-acetylaminofluorene reductase; NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase

Systematic name: 2-acetamidofluorene:NAD(P)+ oxidoreductase

Comments: Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 99890-08-1


1. Gutmann, H.R. and Erickson, R.R. The conversion of the carcinogen N-hydroxy-2-fluorenylacetamide to o-amidophenols by rat liver in vitro. An inducible enzymatic reaction. J. Biol. Chem. 244 (1969) 1729-1740. [PMID: 5780838]

2. Kitamura, S. and Tatsumi, K. Purification of N-hydroxy-2-acetylaminofluorene reductase from rabbit liver cytosol. Biochem. Biophys. Res. Commun. 133 (1985) 67-74. [PMID: 4074379]

[EC created 1989 as EC, transferred 2002 to EC]

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