Reaction: IMP + NH3 + NADP+ = GMP + NADPH + H+
Glossary: IMP = inosine 5'-phosphate
GMP = guanosine 5'-phosphate
Other name(s): guanosine 5'-monophosphate reductase; NADPH:GMP oxidoreductase (deaminating); guanosine monophosphate reductase; guanylate reductase; NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating); guanosine 5'-phosphate reductase
Systematic name: inosine-5'-phosphate:NADP+ oxidoreductase (aminating)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-32-7
References:
1. MacKenzie, J.J. and Sorensen, L.B. Guanosine 5'-phosphate reductase of human erythrocytes. Biochim. Biophys. Acta 327 (1973) 282-294. [PMID: 4149840]
2. Mager, J. and Magasanik, B. Guanosine 5'-phosphate reductase and its role in the interconversion of purine nucleotides. J. Biol. Chem. 235 (1960) 1474-1478.