IUBMB Enzyme Nomenclature


Accepted name: nitrite dismutase

Reaction: 3 nitrite + 2 H+ = 2 nitric oxide + nitrate + H2O

Other name(s): Prolixin S; Nitrophorin 7

Systematic name: nitrite:nitrite oxidoreductase

Comments: Contains ferriheme b. The enzyme is one of the nitrophorins from the salivary gland of the blood-feeding insect Rhodnius prolixus. Nitric oxide produced induces vasodilation after injection. Nitrophorins 2 and 4 can also catalyse this reaction.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. He, C. and Knipp, M. Formation of nitric oxide from nitrite by the ferriheme b protein nitrophorin 7. J. Am. Chem. Soc. 131 (2009) 12042-12043. [PMID: 19655755]

2. He, C., Ogata, H. and Knipp, M. Formation of the complex of nitrite with the ferriheme b β-barrel proteins nitrophorin 4 and nitrophorin 7. Biochemistry 49 (2010) 5841-5851. [PMID: 20524697]

[EC created 2011]

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