IUBMB Enzyme Nomenclature


Accepted name: mycothione reductase

Reaction: 2 mycothiol + NAD(P)+ = mycothione + NAD(P)H + H+

mycothiol = 1-O-[2-(N2-acetyl-L-cysteinamido)-2-deoxy-α-D-glucopyranosyl]-1D-myo-inositol
mycothione = oxidized (disulfide) form of mycothiol

Other name(s): mycothiol-disulfide reductase

Systematic name: mycothiol:NAD(P)+ oxidoreductase

Comments: Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 252212-92-3


1. Patel, M.P. and Blanchard, J.S. Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. Biochemistry 38 (1999) 11827-11833. [PMID: 10512639]

2. Patel, M.P. and Blanchard, J.S. Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects. Biochemistry 40 (2001) 5119-5126. [PMID: 11318633]

[EC created 2002]

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