IUBMB Enzyme Nomenclature


Accepted name: sulfide dehydrogenase

Reaction: hydrogen sulfide + (sulfide)n + NADP+ = (sulfide)n+1 + NADPH + H+

Other name(s): SuDH

Systematic name: hydrogen sulfide,polysulfide:NADP+ oxidoreductase

Comments: A iron-sulfur flavoprotein. In the archaeon Pyrococcus furiosus the enzyme is involved in the oxidation of NADPH which is produced in peptide degradation. The enzyme also catalyses the reduction of sulfur with lower activity.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Ma, K. and Adams, M.W. Sulfide dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus: a new multifunctional enzyme involved in the reduction of elemental sulfur. J. Bacteriol. 176 (1994) 6509-6517. [PMID: 7961401]

2. Hagen, W.R., Silva, P.J., Amorim, M.A., Hagedoorn, P.L., Wassink, H., Haaker, H. and Robb, F.T. Novel structure and redox chemistry of the prosthetic groups of the iron-sulfur flavoprotein sulfide dehydrogenase from Pyrococcus furiosus; evidence for a [2Fe-2S] cluster with Asp(Cys)3 ligands. J. Biol. Inorg. Chem. 5 (2000) 527-534. [PMID: 10968624]

[EC created 2013]

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