IUBMB Enzyme Nomenclature


Accepted name: 4,4'-dithiodibutanoate disulfide reductase

Reaction: 2 4-sulfanylbutanoate + NAD+ = 4,4'-disulfanediyldibutanoate + NADH + H+

Systematic name: 4-sulfanylbutanoate:NAD+ oxidoreductase

Comments: The enzyme, characterized from the bacterium Rhodococcus erythropolis MI2, contains an FMN cofator.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Khairy, H., Wubbeler, J.H. and Steinbuchel, A. Biodegradation of the organic disulfide 4,4'-dithiodibutyric acid by Rhodococcus spp. Appl. Environ. Microbiol. 81 (2015) 8294-8306. [PMID: 26407888]

2. Khairy, H., Wubbeler, J.H. and Steinbuchel, A. The NADH:flavin oxidoreductase Nox from Rhodococcus erythropolis MI2 is the key enzyme of 4,4'-dithiodibutyric acid degradation. Lett. Appl. Microbiol. 63 (2016) 434-441. [PMID: 27564089]

[EC created 2017]

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