IUBMB Enzyme Nomenclature


Accepted name: thioredoxin-disulfide reductase

Reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+

Glossary: The term 'oxidized thioredoxin' has been replaced by 'thioredoxin disulfide' as the former is ambiguous.

Other name(s): NADP-thioredoxin reductase; NADPH-thioredoxin reductase; thioredoxin reductase (NADPH); NADPH2:oxidized thioredoxin oxidoreductase

Systematic name: thioredoxin:NADP+ oxidoreductase

Comments: A flavoprotein (FAD).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9074-14-0


1. Moore, E.C., Reichard, P. and Thelander, L. Enzymatic synthesis of deoxyribonucleotides. V. Purification and properties of thioredoxin reductase from Escherichia coli B. J. Biol. Chem. 239 (1964) 3445-3452.

2. Speranza, M.L., Ronchi, S. and Minchiotti, L. Purification and characterization of yeast thioredoxin reductase. Biochim. Biophys. Acta 327 (1973) 274-281. [PMID: 4149839]

3. Arner, E.S. and Holmgren, A. Physiological functions of thioredoxin and thioredoxin reductase. Eur. J. Biochem. 267 (2000) 6102-6109. [PMID: 11012661]

[EC created 1972 as EC, transferred 2002 to EC]

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