IUBMB Enzyme Nomenclature


Accepted name: thiocyanate desulfurase

Reaction: thiocyanate + 2 ferricytochrome c + H2O = cyanate + sulfur + 2 ferrocytochrome c + 2 H+

Other name(s): TcDH; thiocyanate dehydrogenase

Systematic name: thiocyanate:cytochrome c oxidoreductase (cyanate and sulfur-forming)

Comments: The enzyme, characterized from the haloalkaliphilic sulfur-oxidizing bacterium Thioalkalivibrio paradoxus, contains three copper ions in its active site. It catalyses the direct conversion of thiocyanate into cyanate and elemental sulfur without involvement of molecular oxygen.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Tikhonova, T.V., Sorokin, D.Y., Hagen, W.R., Khrenova, M.G., Muyzer, G., Rakitina, T.V., Shabalin, I.G., Trofimov, A.A., Tsallagov, S.I. and Popov, V.O. Trinuclear copper biocatalytic center forms an active site of thiocyanate dehydrogenase. Proc. Natl. Acad. Sci. USA (2020) . [PMID: 32094184]

[EC created 2020]

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