IUBMB Enzyme Nomenclature


Accepted name: prenylcysteine oxidase

Reaction: an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2

Other name(s): prenylcysteine lyase

Systematic name: S-prenyl-L-cysteine:oxygen oxidoreductase

Comments: A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Zhang, L., Tschantz, W.R. and Casey, P.J. Isolation and characterization of a prenylcysteine lyase from bovine brain. J. Biol. Chem. 272 (1997) 23354-23359. [PMID: 9287348]

2. Tschantz, W.R., Digits, J.A., Pyun, H.J., Coates, R.M. and Casey, P.J. Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase. J. Biol. Chem. 276 (2001) 2321-2324. [PMID: 11078725]

[EC created 2000 as EC, transferred 2002 to EC]

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