Reaction: thioredoxin + an oxidized factor 420 = thioredoxin disulfide + a reduced factor 420
Other name(s): F420-dependent thioredoxin-disulfide reductase; deazaflavin-dependent flavin-containing thioredoxin reductase; (coenzyme F420)-dependent thioredoxin-disulfide reductase
Systematic name: thioredoxin:factor 420 oxidoreductase
Comments: A flavoprotein (FAD). The enzyme is found only in methanogenic archaea living in deep-sea volcanoes, and requires high partial pressure of hydrogen, which effects the reducing potential of the F420/F420H2 pair. cf. EC 1.8.1.9, thioredoxin-disulfide reductase (NADPH).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Susanti, D., Loganathan, U. and Mukhopadhyay, B. A novel F420-dependent thioredoxin reductase gated by low potential FAD: a tool for redox regulation in an anaerobe. J. Biol. Chem. 291 (2016) 23084-23100. [PMID: 27590343]