IUBMB Enzyme Nomenclature


Accepted name: magnesium protoporphyrin IX methyltransferase

Reaction: S-adenosyl-L-methionine + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + magnesium protoporphyrin IX 13-methyl ester

For diagram of reaction click here (chlorophyll biosynthesis).

Other name(s): Mg-protoporphyrin IX methyltransferase; S-adenosylmethionine-magnesium protoporphyrin methyltransferase; magnesium-protoporphyrin O-methyltransferase; (–)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase; S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase; S-adenosylmethioninemagnesium protoporphyrin methyltransferase; S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase

Systematic name: S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9029-82-7


1. Gibson, K.D., Neuberger, A. and Tait, G.H. Studies on the biosynthesis of porphyrin and bacteriochlorophyll by Rhodopseudomonas spheroides. 4. S-Adenosylmethioninemagnesium protoporphyrin methyltransferase. Biochem. J. 88 (1963) 325-334.

2. Shepherd, M., Reid, J.D. and Hunter, C.N. Purification and kinetic characterisation of the magnesium protoporphyrin IX methyltransferase from Synechocystis PCC6803. Biochem. J. 371 (2003) 351-360. [PMID: 12489983]

3. Bollivar, D.W., Jiang, Z.Y., Bauer, C.E. and Beale, S.I. Heterologous expression of the bchM gene product from Rhodobacter capsulatus and demonstration that it encodes S-adenosyl-L-methionine:Mg-protoporphyrin IX methyltransferase. J. Bacteriol. 176 (1994) 5290-5296. [PMID: 8071204]

4. Gibson, L.C. and Hunter, C.N. The bacteriochlorophyll biosynthesis gene, bchM, of Rhodobacter sphaeroides encodes S-adenosyl-L-methionine: Mg protoporphyrin IX methyltransferase. FEBS Lett. 352 (1994) 127-130. [PMID: 7925960]

5. Ebbon, J.G. and Tait, G.H. Studies on S-adenosylmethionine-magnesium protoporphyrin methyltransferase in Euglena gracilis strain Z. Biochem. J. 111 (1969) 573-582. [PMID: 5774480]

[EC created 1965, modified 2003]

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