IUBMB Enzyme Nomenclature


Accepted name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

Reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline

For diagram click here.

Systematic name: S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

Comments: involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3'-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 132084-81-2


1. Frenzel, T., Zenk, M.H. S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway. Phytochemistry 29 (1990) 3505-3511.

[EC created 1999]

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